Statistics show that 25% of all diseases fall under psychiatric diagnosis globally. Antidepressants are not suitable for every patient due to possible side effects. Studies show that psychedelics can treat depression, anxiety, and substance abuse from the desert toad poison.

Some mentally ill may experience deterioration or even a tendency to suicide – this is one of the side effects, which, unfortunately, is paradoxical. Patients may feel like trial rabbits because sometimes they have to try several types of medications before they find the right one.

Magic Toad

It is no longer a novelty that psychedelic mushrooms can treat depression and anxiety. The FDA has already accepted psilocybin as a full-fledged drug. Another magic remedy is the poison from the Sonoran Desert toad (Incilius alvarius).

The Sonoran Desert Toad is widespread throughout northern Mexico and the southwest of the United States. This poisonous amphibian contains the psychedelic compound 5-MeO-DMT, and 5-MeO is, according to research, four to six times more potent than its close relative DMT.

Toad poison, a substance called 5-MeO, has been used by native tribes in South America since ancient times to evoke spiritual experiences. These psychedelics are considered a sacrament by the religious group of the Church of the Tree of Life.

Tobacco distributors in the Caribbean and South America even added a synthesized form of 5-MeO to tobacco products.

Depression and Anxiety

Three hundred sixty-two people at an average age of 48 years participated in the study of the effects of 5-MeO. About half of them suffered from depression, the other half from anxiety.

The study, published in The American Journal of Drug and Alcohol Abuse, reported that 80% of people diagnosed with depression and anxiety experienced an improvement in the condition after taking 5-MeO.


A team of Brazilian researchers examined the effect of 5-MeO on cognitive functions, brain changes affecting attention, and antidepressant effects. The study shows that the compound reduces the level of addiction receptors in the brain.

A study published in Scientific Reports suggests that 5-MeO may help in the treatment of substance abuse.

Another study, published in the Journal of Psychopharmacology, reported that 66% of respondents reported improvement in depression, anxiety, post-traumatic stress disorder, drug use disorders, and alcohol-related symptoms.

“The findings suggest that 5-MeO-DMT … has [a] low potential for addiction and may have psychotherapeutic effects,” the research team said in a report.

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